Mechanisms of bacterial-epithelial interaction in Crohn’s disease

Study of Biochemical and Molecular Changes of Iranian Rice Cultivars in Interaction with Bacterial Pathogen Xanthomonas oryzae pv. oryzae Causes Leaf Blight Disease

Rice bacterial blight caused by Xanthamonos oryzae pv. oryzae is one of the most destructive bacterial diseases of rice in some areas of rice cultivation in the world, especially in the tropics of Asia. The low efficiency of disease management methods, especially chemical methods, has led to more research on recognizing resistant cultivars and understanding resistance mechanisms through the stu...

Genital Involvement In Pre-Pubertal Pediatric Population: A Rare Aspect of Crohn’s Disease

Crohn’s disease is an inflammatory bowel disease (IBD), characterized by chronic intestinal inflammation that causes the loss of immune tolerance leading to bizarre inflammatory signals and disruption of mucosal barriers. Environmental triggers and interaction of genetic determinants also play an indispensible role. In this case report, we present a pre-pubertal girl with intermittent and refra...

N0d2 Gene Expression in Paneth Cells and Monocytes

Introduction: Mutations in the NOD2 gene are associated with the development of Crohn’s disease, an inflammatory disorder of the gastrointestinal tract. The NOD2 protein induces cellular activation in response to the bacterial antigen muramyl dipeptide (MDP). The NOD2 gene is mainly expressed by circulating blood monocytes although NOD2-associated Crohn’s disease involves mainly the terminal il...

The Study of Gastric Mucosa for Possible Bacterial Causative Agent of Crohn’s Disease

Isolated cutaneous Crohn’s disease: A case report

This case report describes a patient with cutaneous signs in the genital and peri-anal region suspicious of Crohn’s disease without any intestinal symptom or sign. Inflammatory bowel disease can be associated with some cutaneous signs. However, in this paper, we report a patient with isolated cutaneous Crohn’s disease which is very rare (less than 100 case reports across the world). Our patient...